Orexin B Peptide
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Orexin B (Hypocretin-2) Selective OX2R Neuropeptide Compound (CAS: 205640-91-1)
A high-purity 28-amino acid linear neuropeptide engineered as a potent, selective agonist for the Orexin Receptor 2 (OX2R). Synthesized to support targeted central nervous system, sleep-wake regulation, narcolepsy therapeutics, and neuro-excitatory signaling research. Features a bio-identical C-terminal amidation for maximal receptor affinity.
Overview
Orexin B (Hypocretin-2) is a naturally occurring endogenous hypothalamic neuropeptide composed of 28 amino acid residues with C-terminal amidation. Derived alongside Orexin A from the prepro-orexin precursor, Orexin B exhibits high target selectivity for the Orexin Receptor 2 (OX2R), displaying approximately 10-fold higher affinity for OX2R over OX1R. This profile makes it an essential reference ligand for mapping OX2R-mediated wakefulness and neural activation pathways.
Key Functional Areas & Mechanism of Action
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OX2R Receptor Selectivity: Acts as a high-affinity ligand for the $G_q/G_i$-protein coupled Orexin Receptor 2 (OX2R), making it a gold-standard compound for receptor binding assays and selective agonist screening.
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Narcolepsy & Sleep-Wake Research: Plays a vital role in stabilizing wake-consolidating neural circuits and preventing cataplexy and REM intrusion, serving as a primary model peptide for narcolepsy therapeutic research.
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Neuro-Modulatory Cascades: Triggers intracellular calcium flux, stimulating monoaminergic and cholinergic neurons in the brainstem and basal forebrain to maintain mental alertness.
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Metabolic Circuitry Interception: Modulates autonomic nervous system signaling, regulating central energy expenditure and feeding behavior pathways.
Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.
Frequently Asked Questions
How isshipped?
Orders are processed and shipped using secure, protective packaging to maintain product integrity during transit.
In what form is supplied?
Shipment is available in freeze-dried solid or liquid form.
How should be stored?
Store sealed vials protected from light, heat, and contamination in a clean laboratory environment.
What vial sizes are available ?
available in multiple vial sizes.
How to place an order?
Contact us via WhatsApp or email to get a quotation and place your order.
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