ARA-290 (Cibinetide) Peptide
Contact us for quotation
Targeted Cellular Protection & Anti-Inflammatory Support (Innate Repair Receptor Agonist) ARA-290 (Cibinetide) is a novel 11-amino-acid peptide derived from erythropoietin (EPO) designed to selectively activate the Innate Repair Receptor (IRR). It promotes tissue protection, reduces non-haematopoietic inflammation, and supports peripheral nerve regeneration without stimulating red blood cell production.
Key Highlights
-
Selective IRR Activation: Specifically targets the Innate Repair Receptor (EPOR/CD131 heterodimer) to trigger innate tissue protective and anti-inflammatory pathways.
-
Non-Erythropoietic Design: Lacks affinity for the classical homodimeric EPO receptor, delivering therapeutic tissue repair benefits without altering hematocrit or red blood cell count.
-
Neuropathic & Nerve Repair Focus: Widely studied for its potential in relieving small fiber neuropathy, dampening neuropathic pain signals, and fostering peripheral nerve recovery.
-
Potent Anti-Inflammatory Action: Attenuates pro-inflammatory cytokine cascades, mitigating localized tissue ischemia and secondary cellular damage.
Mechanism of Action
ARA-290 (Cibinetide) leverages a focused tissue-protective signaling mechanism:
-
Innate Repair Receptor (IRR) Binding: Binds selectively to the heteroreceptor complex exposed on damaged or stressed cell membranes during tissue injury or inflammation.
-
Cytoprotective Signaling: Downregulates nuclear factor kappa B (NF-$\kappa$B) and related inflammatory cascades, preventing cell apoptosis.
-
Nerve & Vascular Regeneration: Facilitates axon regrowth and supports microvascular stability to improve metabolic and neuropathic function in injured tissues.
Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.
Frequently Asked Questions
How isshipped?
Orders are processed and shipped using secure, protective packaging to maintain product integrity during transit.
In what form is supplied?
Shipment is available in freeze-dried solid or liquid form.
How should be stored?
Store sealed vials protected from light, heat, and contamination in a clean laboratory environment.
What vial sizes are available ?
available in multiple vial sizes.
How to place an order?
Contact us via WhatsApp or email to get a quotation and place your order.
Related products
