LL-37 (Cathelicidin) Peptide

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Potent Antimicrobial & Skin Repair Peptide LL-37 (Cathelicidin) is a human-derived host defense peptide renowned for its broad-spectrum antimicrobial activity and powerful tissue regeneration properties. Engineered for advanced cellular research, wound healing studies, and barrier defense assays.

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Description

Key Highlights

  • Broad-Spectrum Antimicrobial Defense: Effective against a wide range of Gram-positive and Gram-negative bacteria, fungi, and enveloped viruses by disrupting microbial cell membranes.

  • Accelerated Wound Healing & Tissue Repair: Promotes re-epithelialization, cell migration, and tissue remodeling, making it a benchmark tool in cutaneous recovery research.

  • Pro-Angiogenic Properties: Stimulates new blood vessel formation (angiogenesis) to support nutrient supply and cellular growth in damaged tissues.

  • Immune & Barrier Modulation: Regulates inflammatory cytokine production and neutralizes bacterial lipopolysaccharides (LPS) to help maintain balanced immune responses.

Mechanism of Action

LL-37 functions as a key effector of the innate immune system:

  1. Membrane Disruption: Adopts an amphipathic alpha-helical structure that selectively targets and permeabilizes negatively charged microbial cell membranes, leading to rapid lysis.

  2. Endothelial & Fibroblast Activation: Interacts with cell-surface receptors (e.g., FPR2) to stimulate endothelial cell proliferation, migration, and vessel tube formation.

  3. LPS Neutralization: Directly binds and neutralizes endotoxins (LPS), preventing excessive immune activation and supporting controlled inflammatory responses.

Additional information
size
Storage & Handling

Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.

FAQ

Frequently Asked Questions

How isshipped?

Orders are processed and shipped using secure, protective packaging to maintain product integrity during transit.

Shipment is available in freeze-dried solid or liquid form.

Store sealed vials protected from light, heat, and contamination in a clean laboratory environment.

available in multiple vial sizes.

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