PTD-DBM Peptide
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Targeted Wnt/β-Catenin Signaling Activation for Hair Follicle Regeneration PTD-DBM is an advanced follicle-stimulating peptide designed to block CXXC5-Dishevelled interactions, preventing Wnt pathway inhibition and promoting robust hair growth, follicle neogenesis, and cellular revitalization.
Key Highlights
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Targeted CXXC5 Inhibition: Specifically disrupts the binding between CXXC5 and Dishevelled (Dvl) proteins, preventing the negative regulation of the Wnt/β-catenin pathway.
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Enhanced Hair Follicle Regeneration: Reactivates dormant hair follicles and induces hair follicle neogenesis for improved density and thickness.
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Superior Cell-Penetrating Efficiency: Fused with a Protein Transduction Domain (PTD) sequence to ensure optimal cellular uptake and tissue penetration.
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Synergistic Compatibility: Demonstrates enhanced efficacy when paired with complementary growth factors or Wnt activators (e.g., Valproic Acid).
Mechanism of Action
PTD-DBM operates through a highly selective pathway to restore native tissue regeneration:
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CXXC5 Disruption: CXXC5 acts as a natural brake on hair growth by binding to Dishevelled (Dvl) and suppressing Wnt signaling. PTD-DBM acts as a competitive peptide that binds to CXXC5.
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Wnt/β-Catenin Activation: By blocking CXXC5, the Wnt/β-catenin cascade remains active, signaling stem cells in the hair bulge to proliferate.
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Anagen Phase Induction: Promotes the transition of hair follicles from the resting phase (telogen) into the active growth phase (anagen).
Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.
Frequently Asked Questions
How isshipped?
Orders are processed and shipped using secure, protective packaging to maintain product integrity during transit.
In what form is supplied?
Shipment is available in freeze-dried solid or liquid form.
How should be stored?
Store sealed vials protected from light, heat, and contamination in a clean laboratory environment.
What vial sizes are available ?
available in multiple vial sizes.
How to place an order?
Contact us via WhatsApp or email to get a quotation and place your order.
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