PE-22-28 Peptide
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Targeted Neurogenesis & Mood Regulation Peptide PE-22-28 is an advanced synthetic derivative of Spadin, specifically engineered to target TREK-1 potassium channels. Recognized in neurobiology research for its rapid-onset neuroprotective properties and potential to support cognitive resilience, neuroplasticity, and balanced mood regulation.
Key Highlights
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Selective TREK-1 Blockade: Specifically binds and inhibits TREK-1 background potassium channels, mimicking key neuroprotective and mood-regulating pathways.
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Rapid-Onset Neural Support: Demonstrates faster functional activation in neural signaling pathways compared to traditional neuroactive compounds in preclinical studies.
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Promotes Neurogenesis & Plasticity: Supports hippocampal cell proliferation and synaptogenesis, crucial for memory, learning, and cognitive adaptability.
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Enhanced Stability Profile: Synthesized as a shorter, optimized peptide fragment (7 amino acids) for increased stability and targeted receptor affinity over parent peptides.
Mechanism of Action
PE-22-28 operates through precise neuronal ion channel modulation:
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TREK-1 Channel Inhibition: By blocking TREK-1 $K^+$ channels, PE-22-28 alters neuronal membrane potential, enhancing cellular excitability in targeted brain regions.
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BDNF Signaling Amplification: Upregulates Brain-Derived Neurotrophic Factor (BDNF) expression, stimulating neurogenesis and reinforcing synaptic connections.
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Serotonergic Pathway Modulation: Synergizes with central neurotransmitter pathways to promote balanced signaling and mood homeostasis.
Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.
Frequently Asked Questions
How isshipped?
Orders are processed and shipped using secure, protective packaging to maintain product integrity during transit.
In what form is supplied?
Shipment is available in freeze-dried solid or liquid form.
How should be stored?
Store sealed vials protected from light, heat, and contamination in a clean laboratory environment.
What vial sizes are available ?
available in multiple vial sizes.
How to place an order?
Contact us via WhatsApp or email to get a quotation and place your order.
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