FOXO4-DRI Peptide
Contact us for quotation
Targeted Senolytic & Anti-Aging Research Peptide FOXO4-DRI is a pioneer senolytic peptide designed to selectively disrupt the FOXO4-p53 interaction. By inducing apoptosis in senescent (“zombie”) cells while sparing healthy tissue, it supports cellular rejuvenation, tissue regeneration, and longevity research.
Key Highlights
-
Targeted Senolytic Action: Selectively induces apoptosis in senescent cells by disrupting the FOXO4-p53 complex without harming normal, healthy cells.
-
Cellular Rejuvenation Support: Aids in clearing accumulated senescent cells to help restore tissue function and reduce age-related inflammatory markers (SASP).
-
Retro-Inverso D-Amino Acid Structure: Engineered with a DRI (D-Retro-Inverso) configuration to significantly improve metabolic stability, enzymatic resistance, and bioavailability in experimental models.
-
Longevity & Tissue Health: Demonstrates broad research utility in tissue regeneration, skin viability, and organ function preservation in aging models.
Mechanism of Action
FOXO4-DRI operates through a highly selective pathway to counter cellular senescence:
-
Disrupting the FOXO4-p53 Binding: In senescent cells, FOXO4 sequesters the tumor suppressor protein p53, preventing p53 from initiating apoptosis. FOXO4-DRI competes with FOXO4 for this binding site.
-
Releasing p53: Once p53 is liberated from FOXO4, it translocates to the mitochondria.
-
Selective Apoptosis Induction: The released p53 triggers mitochondrial-mediated apoptosis, specifically clearing senescent cells from surrounding tissue.
Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.
Frequently Asked Questions
How isshipped?
Orders are processed and shipped using secure, protective packaging to maintain product integrity during transit.
In what form is supplied?
Shipment is available in freeze-dried solid or liquid form.
How should be stored?
Store sealed vials protected from light, heat, and contamination in a clean laboratory environment.
What vial sizes are available ?
available in multiple vial sizes.
How to place an order?
Contact us via WhatsApp or email to get a quotation and place your order.
Related products
