VIP (Vasoactive Intestinal Peptide) Peptide

Overview

Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. Functions as a potent neurotransmitter and neuromodulator, VIP acts through specific G-protein coupled receptors—specifically VPAC1 and VPAC2—to mediate a broad range of physiological pathways across the central nervous system, immune system, and gastrointestinal tract.

Owing to its multifunctional nature, high-purity VIP is an essential research tool in studies focusing on chronic inflammation, neurodegenerative conditions, pulmonary hemodynamics, and cellular signaling networks.

Key Research Highlights & Applications

• Potent Anti-Inflammatory & Immunomodulatory Activity: Studies demonstrate VIP’s capacity to suppress pro-inflammatory cytokines (such as TNF-$\alpha$, IL-6, and IFN-$\gamma$) while promoting anti-inflammatory pathways (including IL-10 upregulation).
• Cardiovascular & Pulmonary Hemodynamics: Acts as a powerful vasodilator, inducing smooth muscle relaxation and supporting research into pulmonary arterial hypertension and microvascular blood flow.
• Neuroprotection & Synaptic Plasticity: VIP protects neuronal tissues against oxidative stress, microglial activation, and excitotoxicity, making it a primary candidate in neurodegenerative research models.
• Gastrointestinal & Secretory Regulation: Regulates intestinal motility, water and electrolyte secretion, and mucosal integrity in GI research frameworks.
• Circadian Rhythm Signaling: Serves as a major neurotransmitter in the suprachiasmatic nucleus (SCN) of the hypothalamus, playing a critical role in synchronizing biological clocks.