PNC-27 Peptide
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Targeted Membrane Disruptor for Specialized Cellular Research PNC-27 Peptide is a synthetic membrane-active peptide derived from the p53 binding domain. Engineered to select for HDM-2 expressing cell lines, it induces rapid transmembrane pore formation and cell lysis, making it an invaluable tool for oncology and membrane dynamics studies.
Key Highlights
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Targeted Membrane Lysis: Specifically targets HDM-2 protein complexes in transformed cell membranes without affecting healthy non-transformed cells.
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Rapid Action Mechanism: Induces direct transmembrane pore formation leading to rapid cell membrane disruption within membrane microdomains.
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Derived from p53 Residues: Features a 32-amino acid sequence combining the p53 binding domain (residues 12–26) with a specialized transmembrane-penetrating leader signal.
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High Purity & Quality Assured: Rigorously tested using HPLC and Mass Spectrometry (MS) to ensure analytical consistency and research reliability.
Mechanism of Action
PNC-27 functions through a distinct dual-domain structural mechanism:
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Targeting & Binding: The p53-derived residues (12–26) attach to HDM-2 (human double minute 2) proteins embedded within target cell membranes.
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Conformational Insertion: Upon binding, the amphipathic alpha-helical structure inserts into the lipid bilayer.
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Membrane Lysis: PNC-27 molecules self-assemble to form oligomeric transmembrane pores, causing rapid loss of membrane integrity and selective necrosis.
Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.
Frequently Asked Questions
How isshipped?
Orders are processed and shipped using secure, protective packaging to maintain product integrity during transit.
In what form is supplied?
Shipment is available in freeze-dried solid or liquid form.
How should be stored?
Store sealed vials protected from light, heat, and contamination in a clean laboratory environment.
What vial sizes are available ?
available in multiple vial sizes.
How to place an order?
Contact us via WhatsApp or email to get a quotation and place your order.
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